Watch Closely (two)diazepam will improve the level or result of midazolam intranasal by affecting hepatic/intestinal enzyme CYP3A4 metabolism.
eslicarbazepine acetate will enhance the degree or influence of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Use Warning/Keep an eye on.
Concomitant usage of benzodiazepines and opioids may well bring about profound sedation, respiratory melancholy, coma, and death. Reserve concomitant prescribing of such medication in sufferers for whom different therapy possibilities are inadequate.
Reserve concomitant prescribing of those drugs in individuals for whom other treatment method choices are inadequate. Restrict dosages and durations to your minimum expected. Keep track of closely for signs of respiratory melancholy and sedation.
lapatinib will boost the degree or effect of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
The above information is provided for typical informational and educational applications only. Specific options may possibly fluctuate and formulary information adjustments. Speak to the relevant program service provider for probably the most latest details.
diltiazem will improve the amount or influence of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
Steer clear of or substitute One more drug for these prescription drugs when attainable. Assess for loss of therapeutic result if medication needs to be coadministered.
The prescriber and caregiver must have a standard understanding of what is and is not an episode of seizures that is appropriate for cure, the timing of administration in relation towards the onset on the episode, the mechanics of administering the drug, how and what to watch subsequent administration, and what would represent an result requiring rapid and direct health care interest
Use Warning/Keep an eye on. Ethinyl estradiol may perhaps inhibit the clearance of benzodiazepines that undergo oxidation, thus escalating serum concentrations of concomitantly administered benzodiazepines.
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artemether/lumefantrine will reduce the extent or effect of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
Reserve concomitant prescribing of these medicine in people for whom other procedure solutions are inadequate. Restrict dosages and durations into the minimal required. Monitor closely for indications of respiratory depression and sedation.
The length of hypnotic effect and the profile of unwelcome adverse consequences may very well be motivated by the distribution and elimination half-life of the administered temazepam and any active metabolites Which may be formed 13. When these kinds of fifty percent-lives are long, the drug or its metabolite(s) may possibly more info accumulate during periods of nightly administration and be related to impairments of cognitive and motor effectiveness through waking hours 13.